Why the study?
Does transgenic SERCA2a gene overexpression improve cardiac contractile function in a murine model of hypothyroidism?
Population
Murine model of hypothyroidism (wild-type and SERCA2a transgenic mice) and euthyroid wild-type mice
Comparison
Transgenic SERCA2a gene overexpression vs Hypothyroid wild-type mice
Design
Preclinical
Authors
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Supports SERCA2a restoration in hypothyroid contractile dysfunction; hypothesis-generating and leaves open human translation.
Does transgenic SERCA2a gene overexpression improve cardiac contractile function in a murine model of hypothyroidism?
Overexpression of SERCA2a in a murine model of hypothyroidism compensates for diminished SERCA2a expression and improves cardiac contractile function.
Wolfgang F. Bluhm (1999) studied this question.
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