Key result
Excess thyroid hormone in rats causes myocardial hypertrophy and significant mechanical insufficiency upon SERCA2 inhibition.
Why the study?
Does prolonged exposure to excess thyroid hormone alter myocardial mechanical function and SERCA2 activity in a rat model?
Population
16-week-old Wistar rats weighing 400-420 g (n=27)
Comparison
3,5,3'-Triiodo-L-thyronine 20-40 µg/kg… vs Vehicle subcutaneously daily for 4 weeks
Design
Preclinical
Follow-up
4 weeks
Authors
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Hyperthyroid rat hearts exhibit SERCA2-dependent mechanical vulnerability; leaves open relevance to human thyrotoxic cardiomyopathy or ischemia susceptibility.
Does prolonged exposure to excess thyroid hormone alter myocardial mechanical function and SERCA2 activity in a rat model?
Absolute Event Rate: 9.4% vs 11.7%
p-value: p=<0.05
Prolonged exposure to excess thyroid hormone causes myocardial hypertrophy and augments SERCA2 activity, which may lead to oxygen wastage and increased susceptibility to ischemia-reperfusion injury.
Takeuchi et al. (2003) studied Hyperthyroidism (n=35). 3,5,3'-Triiodo-L-thyronine (T3) vs. Vehicle was evaluated on Myocardial mechanical efficiency (LVDP/MVO2) after SERCA2 inhibition with thapsigargin (p=<0.05). Prolonged exposure to excess thyroid hormone in rats caused myocardial hypertrophy and augmented SR Ca2+-ATPase activity, leading to significant mechanical insufficiency upon SERCA2 inhibition.
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