Why the study?
Does thyroid hormone (T3) improve myocardial function and restore SERCA2 and GLUT4 protein levels in an early failing hypertrophied rat heart model?
Population
Hypertrophied rat hearts and hypertrophied H9c2 rat heart myoblasts
Comparison
3,5,3'-triiodo-L-thyronine 20-40 microg/kg… vs Untreated hypertrophied rat hearts/myocytes
Design
Preclinical
Follow-up
16 and 26 weeks (in vivo); up to 10 days (in vitro)
Authors
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T3 may merit further preclinical testing in early HF; leaves open clinical translation and metabolic effects.
Does thyroid hormone (T3) improve myocardial function and restore SERCA2 and GLUT4 protein levels in an early failing hypertrophied rat heart model?
Thyroid hormone partially improves myocardial function in early heart failure by restoring SERCA2 protein levels, but does not correct impaired glucose metabolism (GLUT4).
Minakawa et al. (2003) studied this question.
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