Population
Rats rendered hypothyroid by ingestion of propylthiouracil
Comparison
Triiodo-L-thyronine 7 microg/day by constant… vs Hypothyroid state (untreated) and euthyroid state
Design
Preclinical
Follow-up
7 days
Authors
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May link chamber-specific calcium transporter changes to thyrotoxic arrhythmias; hypothesis-generating in animals and requires human validation.
Thyroid hormone regulates cardiac calcium transporter proteins in a chamber-specific manner, which may explain the occurrence of atrial arrhythmias in thyrotoxicosis.
Shenoy et al. (2001) studied this question.
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