July 1, 1990Journal of Applied Physiology

Effect of thyroid state on cardiac myosin P-light chain phosphorylation during exercise

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Population

Rats with thyroid deficiency (TD) or hyperthyroidism (H), and normal controls (NC)

Comparison

Thyroid deficiency or hyperthyroidism state vs Normal controls (NC)

Design

Preclinical

Authors

DFDaniel P. FitzsimonsUniversity of Idaho PBP. W. BodellUniversity of California, Irvine RHR. E. HerrickIrvine Valley College

Discussion

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Implication

Thyroid effects on myocardial performance may be independent of P-LC(P) during exercise; leaves open translation to human thyroid-cardiac disease.

Structured PICO

Population

Rats with thyroid deficiency (TD) or hyperthyroidism (H), and normal controls (NC)

Intervention

Thyroid deficiency (TD) or hyperthyroidism (H) state

Comparator

Normal controls (NC)

Outcome

Cardiac myosin light chain 2 phosphorylation [P-LC(P)] and in vivo cardiovascular functional capacity at rest and during exercisesurrogate

Thyroid state exerts a profound impact on intrinsic myocardial functional state but little control over cellular processes regulating P-LC(P) during rest and exercise.

Cite This Study

Fitzsimons et al. (1990) studied this question.

synapsesocial.com/papers/6a7d16db342883c6199ffdc6 https://doi.org/10.1152/jappl.1990.69.1.313

View Full Paper

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Implication

Thyroid effects on myocardial performance may be independent of P-LC(P) during exercise; leaves open translation to human thyroid-cardiac disease.

Effect of thyroid state on cardiac myosin P-light chain phosphorylation during exercise

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of thyroid state on cardiac myosin P-light chain phosphorylation during exercise

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider