Key result
Hypothyroidism in rats increases ventricular calcium channel density by ~50% and modestly decreases beta-adrenoceptors.
Authors
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Does not warrant clinical changes in hypothyroidism; extends preclinical models of cardiac receptor remodeling but leaves human relevance open.
Kragie et al. (1993) studied Hypothyroidism. Thyroidectomy vs. Sham-operated euthyroid controls was evaluated on Densities of calcium channels, beta-adrenoceptors, and atrial muscarinic receptors. Hypothyroidism induced by thyroidectomy in male rats increased ventricular calcium channel density by 50% and modestly decreased beta-adrenoceptors compared to euthyroid controls.
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