November 1, 1998Cardiovascular ResearchOpen Access

Effects of thyroid status on expression of voltage-gated potassium channels in rat left ventricle

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Population

Rat model for evaluating left ventricle voltage-gated potassium channel expression

Comparison

Methimazole for 4 weeks to induce… vs Control rats

Design

Preclinical

Follow-up

4 weeks

Authors

ANAtsushi NishiyamaTokyo Dental College

Discussion

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Implication

Hypothesis-generating for thyroid effects on ventricular repolarization; leaves open translation to human electrophysiology.

Structured PICO

Population

Rat model for evaluating left ventricle voltage-gated potassium channel expression

Intervention

Methimazole (MMI) for 4 weeks to induce hypothyroidism, with or without L-thyroxine (T4), propranolol (Pro), or isoproterenol (Iso) for the last 7 days

Comparator

Control rats

Outcome

mRNA levels of Kv1.2, Kv1.4, Kv1.5, Kv2.1, Kv4.2 and Kv4.3 in the left ventricles measured by ribonuclease protection assaysurrogate

Thyroid hormone directly and differentially regulates the expression of various voltage-gated potassium channel alpha-subunits in the rat left ventricle, independent of beta-adrenergic signaling.

Cite This Study

Atsushi Nishiyama (1998) studied this question.

synapsesocial.com/papers/6a7b37c702ab7a73dd0340d3 https://doi.org/10.1016/s0008-6363(98)00135-7

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Effects of thyroid status on expression of voltage-gated potassium channels in rat left ventricle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of thyroid status on expression of voltage-gated potassium channels in rat left ventricle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider