Population
Cultured neonatal rat ventricular myocytes (from 1- to 2-day-old rats) and adult rat hearts
Comparison
Tri-iodothyronine (T3, 100 nM) vs Untreated neonatal rat ventricular myocytes
Design
Preclinical
Authors
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Hypothesis-generating for thyroid hormone in rodent cardiac maturation; leaves open translational relevance to human neonatal electrophysiology or arrhythmia risk.
Thyroid hormone induces electrophysiological and molecular changes in neonatal rat ventricular myocytes that mimic normal postnatal development of K+ currents.
Wickenden et al. (1997) studied this question.
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