Key result
Acute application of triiodothyronine (0.1 microM) for 5 minutes significantly shortened action potential duration in hypothyroid rat ventricular myocytes by 24% (from 151 to 115 ms).
Population
Ventricular myocytes isolated from euthyroid and hypothyroid rats
Comparison
Triiodothyronine 0.1 microM applied acutely for… vs Baseline and euthyroid vs hypothyroid myocytes
Design
Preclinical
Follow-up
5 minutes
Authors
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Should not change clinical practice; hypothesis-generating for acute T3 effects on ventricular repolarization.
Absolute Event Rate: 115% vs 151%
Acute application of T3 shortens action potential duration in hypothyroid rat ventricular myocytes, demonstrating nongenomic electrophysiological effects of thyroid hormone.
Sun et al. (2000) studied Hypothyroidism (rat ventricular myocytes). Triiodothyronine (T3) vs. Baseline / Euthyroid myocytes was evaluated on Action potential duration (APD90). Acute application of triiodothyronine (0.1 microM) for 5 minutes significantly shortened action potential duration in hypothyroid rat ventricular myocytes by 24% (from 151 to 115 ms).
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