Why the study?
Does TSH directly modulate cardiac electrical activity in adult rat ventricular myocytes?
Population
Adult rat left ventricles and isolated rat adult ventricular myocytes
Design
Preclinical
Follow-up
24 hours
Authors
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Elevated TSH may drive repolarization abnormalities in hypothyroidism independently of T3; leaves open human translation.
Does TSH directly modulate cardiac electrical activity in adult rat ventricular myocytes?
TSH directly modulates cardiac electrical activity by reducing Ito and IK1 currents, suggesting that repolarization abnormalities in hypothyroidism may be driven by elevated TSH rather than low T3 alone.
Alonso et al. (2015) studied this question.
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