Key result
Acute exposure to T3 (1 microM) significantly increased the single IK1 open probability by 42 +/- 6% at -40 mV (P < 0.0001) in guinea pig ventricular myocytes.
Population
Guinea pig ventricular myocytes
Design
Preclinical
Follow-up
up to 25 minutes
Authors
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T3-IK1 effects may explain APD shortening in hyperthyroidism; leaves open translation to human arrhythmia risk.
Effect estimate: Increased IK1 by 68 +/- 7% at -40 mV
p-value: p=<0.0001
T3 enhances inward rectifier potassium channel (IK1) currents by shortening interburst duration, providing a potential mechanism for shortened action potential duration in hyperthyroidism.
Sakaguchi et al. (1996) studied Guinea pig ventricular myocytes. 3,3',5-triiode-L-thyronine (T3) was evaluated on Inward rectifier potassium channel (IK1) currents and action potential duration (Increased IK1 by 68 +/- 7% at -40 mV, p=<0.0001). Acute exposure to T3 (1 microM) significantly increased the single IK1 open probability by 42 +/- 6% at -40 mV (P < 0.0001) in guinea pig ventricular myocytes.
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