August 1, 1993Circulation ResearchOpen Access

Bursting of cardiac sodium channels after acute exposure to 3,5,3'-triiodo-L-thyronine.

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Why the study?

Does acute exposure to T3 increase burst-mode gating of Na+ channels in rabbit ventricular myocytes?

Population

Rabbit ventricular myocytes

Comparison

Acute exposure to 3,5,3'-triiodo-L-thyronine at… vs Control (without T3)

Design

Preclinical

Authors

SDSamuel C. DudleyElectrophysiology CBClive M. BaumgartenVirginia Commonwealth University

Discussion

Member takes

Implication

T3-induced Na+ channel bursting in rabbit myocytes may explain hyperthyroid arrhythmias; hypothesis-generating for extranuclear effects in humans.

Structured PICO

Does acute exposure to T3 increase burst-mode gating of Na+ channels in rabbit ventricular myocytes?

Population

Rabbit ventricular myocytes

Intervention

Acute exposure to 3,5,3'-triiodo-L-thyronine (T3) at 5 or 50 nM

Comparator

Control (without T3)

Outcome

Burst-mode gating of Na+ channels (measured as percentage of long events, %LE)surrogate

Acute exposure to T3 induces Na+ channel bursting via an extranuclear mechanism, which may contribute to arrhythmias in hyperthyroidism and positive inotropic effects in stunned/ischemic myocardium.

Cite This Study

Dudley et al. (1993) studied this question.

synapsesocial.com/papers/6a71a2fb5d37378ac1debc7b https://doi.org/10.1161/01.res.73.2.301

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Implication

T3-induced Na+ channel bursting in rabbit myocytes may explain hyperthyroid arrhythmias; hypothesis-generating for extranuclear effects in humans.

Bursting of cardiac sodium channels after acute exposure to 3,5,3'-triiodo-L-thyronine.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Bursting of cardiac sodium channels after acute exposure to 3,5,3'-triiodo-L-thyronine.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider