Key result
T3 acts on the cytosolic side of the membrane to acutely activate INa, an effect that is synergistically enhanced 5.8-fold by pertussis toxin-sensitive G protein modulation.
Population
Adult guinea pig ventricular myocytes
Comparison
Liothyronine (3,5,3'-triiodo-L-thyronine, T) 1… vs Control conditions
Design
Preclinical
Authors
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Should not change practice; leaves open whether cytosolic T3-G protein synergy on INa translates to human electrophysiology.
Effect estimate: 5.8-fold increase
T3 acutely activates Na+ channel currents on the cytosolic side of the membrane, an effect that is greatly magnified by pertussis toxin-sensitive G protein modulation.
Sen et al. (2002) studied Adult guinea pig ventricular myocytes. Liothyronine (T3) was evaluated on Na+ channel current (INa) properties and channel open probability (5.8-fold increase). T3 acts on the cytosolic side of the membrane to acutely activate INa, an effect that is synergistically enhanced 5.8-fold by pertussis toxin-sensitive G protein modulation.
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