Population
Mice with 5-propyl-2-thiouracil-induced hypothyroidism and enzymatically isolated myocytes from right…
Comparison
5-propyl-2-thiouracil-induced hypothyroidism vs Control/euthyroid mice (implied)
Design
Preclinical
Authors
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Hypothesis-generating for regional repolarization effects in hypothyroidism; human studies required before clinical relevance can be assessed.
Experimental hypothyroidism induces regional differences in action potential prolongation and repolarization inhomogeneity due to uneven decreases in the transient outward potassium current (Ito,fast).
Ferrer et al. (2011) studied this question.
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