Key result
Administration of T3 to hypothyroid rats rapidly restored ventricular Kv1.5 mRNA to euthyroid control levels within 1 hour, while atrial expression remained unaltered.
Population
Euthyroid and hypothyroid rats, and primary cultures of rat atrial and ventricular myocytes
Comparison
Administration of T3 (thyroid hormone) vs Euthyroid rats and untreated hypothyroid rats
Design
Preclinical
Authors
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Rapid T3 effects on rat ventricular Kv1.5 suggest chamber-specific ion channel control; leaves open human relevance and arrhythmia implications.
p-value: p=< 0.01
Thyroid hormone rapidly and chamber-specifically regulates the expression of the voltage-gated K+ channel Kv1.5 in rat ventricular myocytes.
Kaie Ojamaa (1999) studied Hypothyroidism (animal model). Thyroid hormone (T3) vs. Hypothyroid control was evaluated on Kv1.5 mRNA content in left ventricles (p=< 0.01). Administration of T3 to hypothyroid rats rapidly restored ventricular Kv1.5 mRNA to euthyroid control levels within 1 hour, while atrial expression remained unaltered.
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