Key result
Administration of T3 to hypothyroid rats restored ventricular Kv1.5 mRNA to control levels within 1 hour, demonstrating rapid and chamber-specific regulation of this potassium channel gene.
Population
Euthyroid and hypothyroid rats, and primary cultures of rat atrial and ventricular myocytes
Comparison
Administration of T3 (thyroid hormone) vs Hypothyroid rats without T3 treatment and…
Design
Preclinical
Follow-up
1 hour
Authors
Loading...
Caution against clinical extrapolation from rats; leaves open whether T3 rapidly modulates human ventricular repolarization.
p-value: p=<0.01
Thyroid hormone rapidly and chamber-specifically regulates the expression of the voltage-gated K+ channel Kv1.5 in rat ventricular myocardium.
Ojamaa et al. (1999) studied Thyroid hormone regulation of cardiac genes. Thyroid hormone (T3) vs. Hypothyroid control was evaluated on Kv1.5 mRNA content in left ventricles (p=<0.01). Administration of T3 to hypothyroid rats restored ventricular Kv1.5 mRNA to control levels within 1 hour, demonstrating rapid and chamber-specific regulation of this potassium channel gene.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: