Population
Rat isolated atria and ventricular membrane fragments from hypophysectomized, thyroidectomized, and control…
Comparison
Thyroxine, cortisone, sympathetic denervation… vs Control rats, or untreated…
Design
Preclinical
Authors
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May inform preclinical thyroid-cardiac signaling models; leaves open human translation and should not change practice.
Thyroid hormones reciprocally regulate cardiac alpha1- and beta-adrenoceptor density, requiring intact sympathetic innervation but not normal neurotransmitter stores.
Kunos et al. (1980) studied this question.
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