Key result
New-onset AF during ACS linked to ~62% higher inhospital mortality versus sinus rhythm.
Why the study?
The prognostic ability of atrial fibrillation in acute coronary syndromes and the impact of timing of AF on patient outcomes are unclear and understudied.
Does the presence of new-onset or previous atrial fibrillation increase inhospital mortality in patients with acute coronary syndromes?
Population
39,237 consecutive ACS patients in the ARIAM registry from 2001 to 2011
Comparison
New-onset AF and previous AF vs sinus rhythm patients
Design
Cohort study
Follow-up
Inhospital
Authors
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Supports close monitoring of ACS patients developing AF; leaves open whether interventions improve survival.
Cohort (n=39,237)
Does the presence of new-onset or previous atrial fibrillation increase inhospital mortality in patients with acute coronary syndromes?
Hazard Ratio: 1.62 (95% CI 1.09–2.89)
Absolute Event Rate: 14% vs 5.2%
p-value: p=<0.001
New-onset atrial fibrillation during acute coronary syndromes is independently associated with a significant increase in inhospital mortality.
Almendro‐Delia et al. (2013) conducted a cohort in Acute coronary syndromes (n=39,237). New-onset atrial fibrillation vs. Sinus rhythm (non-AF) was evaluated on Inhospital mortality (HR 1.62, 95% CI 1.09-2.89, p=<0.001). New-onset atrial fibrillation during acute coronary syndromes was associated with increased inhospital mortality compared to sinus rhythm (14% vs 5.2%; HR 1.62, 95% CI 1.09-2.89, p<0.001).
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