Key result
Sequencing the mouse gamma-renin gene reveals its complete amino acid sequence and tissue expression.
Why the study?
Mouse gamma-renin is a unique serine protease with an unusual cleavage pattern, and its gene sequence and tissue expression were not previously characterized.
The study identified the complete amino acid sequence of mouse gamma-renin, providing insights into its unusual cleavage pattern and tissue expression.
Enables targeted mouse studies of gamma-renin; leaves open any role in human cardiovascular disease.
Mouse gamma-renin is a member of the group of serine proteases known as glandular kallikreins. These highly homologous proteins process a diverse range of growth factors and hormones to their biologically active form, usually by cleavage at a basic residue. gamma-Renin, however, cleaves at a Leu-Leu bond in a similar fashion to renin. We have identified and sequenced the gene and a cDNA encoding gamma-renin. The complete predicted amino acid sequence was determined, and residues that may be important in the unusual cleavage pattern exhibited by gamma-renin are discussed. The nucleotide sequence enabled design of a gene-specific oligodeoxyribonucleotide which was used to determine in which mouse tissues gamma-renin is expressed.
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Drinkwater et al. (1988) studied this question. The gene and cDNA encoding mouse gamma-renin were identified and sequenced, revealing its complete predicted amino acid sequence and enabling determination of its tissue expression.
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