What does this research mean for the field?

Periodontitis is not associated with significant differences in circulating inflammatory or acute-phase reactants across coronary artery disease groups, although age significantly predicts CAD. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 5, 2018Journal of Applied Oral ScienceOpen Access

Circulation levels of acute phase proteins pentraxin 3 and serum amyloid A in atherosclerosis have correlations with periodontal inflamed surface area

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Coronary artery disease and periodontitis (n=77). Intervention: Periodontitis and periodontal inflamed surface area vs. No periodontitis. Primary outcome: Serum levels of acute phase reactants and inflammatory cytokines (IL-1, IL-6, IL-10, TNF-α, SAA, PTX3, hs-CRP) (p=>0.0125).

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Key result

Periodontitis shows no association with serum inflammatory markers across CAD groups.

P>0.0125
n=77

Why the study?

The systemic inflammatory burden linking periodontitis and coronary artery disease involves circulating cytokines and mediators, but their correlation with periodontal inflamed surface area in CAD patients is unclear.

Comparison

Groups based on CAD and periodontitis status: CAD+/periodontitis+, CAD+/periodontitis-, CAD-/periodontitis+, CAD-/periodontitis-

Design

Cross-sectional study

Authors

BTBaşak TemelliSüleyman Demirel University ZAZühal Yetkin AyTokyo University of Agriculture HSHasan Basri SavaşMardin Artuklu University

Discussion

Member takes

Implication

Does not support periodontitis as modifier of inflammation in CAD; hypothesis-generating for PISA links to PTX3/SAA only in non-CAD patients.

Study Design

Type

Cross-Sectional (n=77)

Structured PICO

Population

77 patients aged 30 to 75 years undergoing coronary angiography for suspected CAD, stratified by CAD and periodontitis status.

Outcome

Serum levels of interleukin (IL)-1, IL-6, IL-10, tumor necrosis factor (TNF)-α, serum amyloid A (SAA), pentraxin (PTX) 3, and high-sensitivity C-reactive protein (hs-CRP)surrogate

Main Result

p-value: p=>0.0125

Periodontal inflamed surface area correlates with acute phase proteins PTX3 and SAA in patients without coronary artery disease, suggesting a link between periodontal inflammation and systemic inflammatory markers.

Limitations

Small population size
Lack of age group stratification
Small sample size
Lack of age stratification

Cite This Study

Temelli et al. (2018) conducted a cross-sectional in Coronary artery disease and periodontitis (n=77). Periodontitis and periodontal inflamed surface area vs. No periodontitis was evaluated on Serum levels of acute phase reactants and inflammatory cytokines (IL-1, IL-6, IL-10, TNF-α, SAA, PTX3, hs-CRP) (p=>0.0125). Periodontitis was not associated with significant differences in serum inflammatory parameters across CAD groups (p>0.0125), though age significantly predicted CAD (OR 1.17; 95% CI 1.08-1.27; p<0.001).

synapsesocial.com/papers/6aad09bf0914932f8ced75c5 https://doi.org/10.1590/1678-7757-2017-0322

Topics

Coronary artery disease

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Implication

Does not support periodontitis as modifier of inflammation in CAD; hypothesis-generating for PISA links to PTX3/SAA only in non-CAD patients.

Circulation levels of acute phase proteins pentraxin 3 and serum amyloid A in atherosclerosis have correlations with periodontal inflamed surface area

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Topics

Circulation levels of acute phase proteins pentraxin 3 and serum amyloid A in atherosclerosis have correlations with periodontal inflamed surface area

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Topics

Also Consider