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September 18, 2026

Lipopolysaccharide-induced glycolytic reprogramming drives H3K18 lactylation-mediated inflammatory injury in buffalo mammary epithelial cells.

Peng Xiao Tian Xin-Ru Zhou Jin-chen Bo Zhang Meng-qi Li Chunyan Yang Haiying Zheng Chen Meng-Jiao Xiaogan Yang Jiang-Hua Shang Xingwei Liang

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Abstract

reduced lactate accumulation, decreased H3K18la levels, and substantially attenuated inflammatory injury in BuMECs. Together, these findings identify the HK2-lactate-H3K18la axis as a central mechanism in LPS-induced inflammatory injury in BuMECs and underscore its potential as a therapeutic target for alleviating mastitis and enhancing mammary health in dairy buffalo.

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Xiao et al. (2026) studied this question.

synapsesocial.com/papers/6aad0a69de0393d728b88d9c https://doi.org/10.24272/j.issn.2095-8137.2025.523

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