Review demonstrates advanced diffusion MRI efficacy for microstructural damage in stroke survivors, highlighting its biomarker potential for post-stroke depression.
Key Points
To synthesize the biophysical principles, clinical applications, limitations, and future translational directions of neurite orientation dispersion and density imaging (NODDI) in stroke.
Reviewed biophysical principles and magnetic resonance imaging literature evaluating NODDI applications across ischemic and hemorrhagic stroke.
Assessed NODDI-derived metric performance, specifically orientation dispersion index (ODI) and isotropic volume fraction (ISO), against conventional diffusion tensor imaging parameters for neurological and neuropsychiatric outcomes.
NODDI provides objective quantification of neurite damage, microstructural remodeling, and tissue repair processes in early-stage stroke that conventional imaging fails to capture.
NODDI-derived ODI and ISO metrics detect distinct microstructural disruptions within emotion-related white matter pathways specific to post-stroke depression, outperforming standard diffusion tensor imaging metrics.