Neurite orientation dispersion and density imaging (NODDI) has been broadly used in diffusion MRI for the characterisation of tissue microstructure in healthy ageing and the diseased brain. However, the compartment-specific volume fractions provided by NODDI suffer from echo-time (TE) dependence due to differences in the compartment-specific transverse relaxation times. The recently proposed multi-TE NODDI (MTE-NODDI) model provides both TE-independent compartmental volume fractions and compartment-specific transverse relaxation times. Here we aim to assess the benefits and limitations of using MTE-NODDI for studying the brain tissue microstructure affected by transient ischaemic stroke in MCAo animal models.
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Farrher et al. (2024) studied this question.
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