Multiparametric flow-cytometry minimal residual disease before hematopoietic stem cell transplantation predicts outcome in pediatric acute myeloid leukemia

Barbara Buldini; Pietro Merli; Elena Varotto; Riccardo Masetti; Maria Gabelli; Marco Zecca; Davide Leardini; Pamela Scarparo; Maddalena Benetton; Luisa Strocchio; Franca Fagioli; Alessandra Biffi; Adriana Balduzzi; Martina Pigazzi; Daria Pagliara; Franco Locatelli

doi:10.3324/haematol.2026.300844

September 17, 2026HaematologicaOpen Access

Multiparametric flow-cytometry minimal residual disease before hematopoietic stem cell transplantation predicts outcome in pediatric acute myeloid leukemia

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Key Points

To assess whether minimal residual disease detected by multiparametric flow cytometry before hematopoietic stem cell transplantation predicts clinical outcomes in pediatric acute myeloid leukemia.
Measured minimal residual disease (MRD) using multiparametric flow cytometry prior to allogeneic hematopoietic stem cell transplantation.
Evaluated pediatric patients undergoing hematopoietic stem cell transplantation for acute myeloid leukemia.
Pre-transplant minimal residual disease detected by multiparametric flow cytometry strongly associates with adverse clinical outcomes and increased risk of leukemia relapse.
Patients with detectable residual leukemic burden experience significantly poorer post-transplant survival compared to those achieving flow-cytometric negative remission.

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Implication

Clinical study demonstrates pre-transplant flow-cytometry minimal residual disease predicts outcomes in pediatric acute myeloid leukemia, highlighting its role in risk stratification.

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Cite This Study

Buldini et al. (2026) studied this question.

synapsesocial.com/papers/6aad0b5cde0393d728b89a95 https://doi.org/10.3324/haematol.2026.300844

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Multiparametric flow-cytometry minimal residual disease before hematopoietic stem cell transplantation predicts outcome in pediatric acute myeloid leukemia

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

Multiparametric flow-cytometry minimal residual disease before hematopoietic stem cell transplantation predicts outcome in pediatric acute myeloid leukemia

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

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