What question did this study set out to answer?

To determine whether gut dysbiosis in cats with diarrhea impairs intestinal barrier integrity and provokes gut inflammation using an in vivo recipient model.

September 18, 2026Veterinary SciencesOpen Access

Gram-Negative Bacterial Overgrowth Predominated by: Potential Association with Intestinal Barrier Impairment and Inflammatory Diarrhea in Cats

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Authors

JWJing WangShangluo University XZXinhui ZhangTang Du Hospital XSXinran SongShangluo University

Discussion

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Implication

Experimental study demonstrates gut inflammation and barrier impairment from feline diarrheal microbes in mice, indicating Escherichia-Shigella overgrowth drives feline diarrhea.

Key Points

To determine whether gut dysbiosis in cats with diarrhea impairs intestinal barrier integrity and provokes gut inflammation using an in vivo recipient model.
Transplanted fecal microbiota from diarrheic cats into antibiotic-treated recipient mice via oral gavage.
Assessed recipient mouse colonic pathology and mucosal integrity through histological analysis of neutrophil and macrophage infiltration.
Profiled fecal bacterial composition and quantified Gram-negative bacterial load in healthy versus diarrheic cats using 16S rRNA gene sequencing.
Fecal microbes from diarrheic cats caused weight loss, intestinal barrier damage, and pronounced colonic infiltration of neutrophils and macrophages in recipient mice.
16S rRNA sequencing showed a significantly higher relative abundance of Escherichia–Shigella in diarrheic cats compared with healthy controls.
Quantitative fecal analysis demonstrated an overall significantly higher bacterial load of Gram-negative bacteria in cats with diarrhea compared to healthy cats.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6aad0b98de0393d728b89f2f https://doi.org/10.3390/vetsci13090976

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September 18, 2026Veterinary SciencesOpen Access

Gram-Negative Bacterial Overgrowth Predominated by: Potential Association with Intestinal Barrier Impairment and Inflammatory Diarrhea in Cats

View Full Paper

Ask AI

Bookmark

Authors

JWJing WangShangluo University XZXinhui ZhangTang Du Hospital XSXinran SongShangluo University

Discussion

Member takes

Implication

Experimental study demonstrates gut inflammation and barrier impairment from feline diarrheal microbes in mice, indicating Escherichia-Shigella overgrowth drives feline diarrhea.

Key Points

To determine whether gut dysbiosis in cats with diarrhea impairs intestinal barrier integrity and provokes gut inflammation using an in vivo recipient model.
Transplanted fecal microbiota from diarrheic cats into antibiotic-treated recipient mice via oral gavage.
Assessed recipient mouse colonic pathology and mucosal integrity through histological analysis of neutrophil and macrophage infiltration.
Profiled fecal bacterial composition and quantified Gram-negative bacterial load in healthy versus diarrheic cats using 16S rRNA gene sequencing.
Fecal microbes from diarrheic cats caused weight loss, intestinal barrier damage, and pronounced colonic infiltration of neutrophils and macrophages in recipient mice.
16S rRNA sequencing showed a significantly higher relative abundance of Escherichia–Shigella in diarrheic cats compared with healthy controls.
Quantitative fecal analysis demonstrated an overall significantly higher bacterial load of Gram-negative bacteria in cats with diarrhea compared to healthy cats.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6aad0b98de0393d728b89f2f https://doi.org/10.3390/vetsci13090976

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