Key result
Fixed-dose LAMA/LABA combinations demonstrate cardiovascular safety and improve cardiac pumping function in COPD.
Why the study?
COPD is characterized by decreased pulmonary function and cardiac contractility, necessitating evaluation of the cardiovascular safety and effectiveness of fixed long-acting bronchodilator combinations.
Do fixed dose LAMA/LABA combinations maintain cardiovascular safety and affect cardiac contractility in patients with COPD?
Do fixed dose LAMA/LABA combinations maintain cardiovascular safety and affect cardiac contractility in patients with COPD?
Fixed-dose LAMA/LABA combinations appear safe for the cardiovascular system and may improve cardiac pumping function in patients with COPD.
May support CV safety of LAMA/LABA in COPD; leaves open confirmation of cardiac pumping benefits in prospective trials.
At present time, long-acting bronchodilators are the main class of drugs for basis therapy of chronic obstructive pulmonary disease (COPD). COPD is characterized not only by a decrease in pulmonary function parameters, but also by a decline in cardiac contractility. The article presents the results of studies of four approved fixed long-acting anticholinergic drugs/long-acting beta2-agonists in the Russian Federation, according their effect on the cardiovascular system. The safety of LAMA/ LABA was proved in terms of relation to the cardiovascular system, additionally the positive effect on the pumping function of the heart was shown in patients with COPD, which confirms the value of dual bronchodilators for COPD treatment.
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И. В. Лещенко (2018) conducted a review in chronic obstructive pulmonary disease (COPD). Fixed dose long-acting anticholinergic drugs/long-acting beta2-agonists (LAMA/LABA) was evaluated on Effect on the cardiovascular system and pumping function of the heart. Fixed dose LAMA/LABA combinations demonstrated cardiovascular safety and a positive effect on the pumping function of the heart in patients with COPD.
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