Key result
The rs4916251 SNP is linked to ~10% higher AAA risk.
Why the study?
The genetic determinants of expansive remodelling, a compensatory arterial enlargement process in response to atherosclerosis, are poorly characterized.
Is common genetic variation at 1q24.3 associated with expansive vascular remodelling and risk of abdominal aortic aneurysm?
Meta-Analysis (n=48,637)
Yes
Is common genetic variation at 1q24.3 associated with expansive vascular remodelling and risk of abdominal aortic aneurysm?
Odds Ratio: 1.1 (95% CI 1.03–1.17)
p-value: p=2.8 × 10(-3)
Common genetic variation at 1q24.3 is associated with expansive vascular remodelling and an increased risk of abdominal aortic aneurysm, suggesting shared pathways in systemic vascular remodelling.
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Should not alter AAA risk assessment; leaves open shared pathways in vascular remodelling.
Harrison et al. (2012) conducted a meta-analysis in Abdominal Aortic Aneurysm (AAA) and common carotid artery remodelling (n=48,637). rs4916251 SNP on Chromosome 1q24.3 vs. Reference allele was evaluated on Presence of Abdominal Aortic Aneurysm (AAA) (OR 1.10, 95% CI 1.03-1.17, p=2.8 × 10(-3)). The rs4916251 SNP on chromosome 1q24.3 was significantly associated with the presence of abdominal aortic aneurysm (OR 1.10; 95% CI 1.03-1.17; p=2.8×10^-3).
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