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August 5, 2016Virology JournalOpen Access

Occurrence and sequence analysis of porcine deltacoronaviruses in southern China

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Key result

Porcine deltacoronavirus appears in ~1% of diarrheal swine, exclusively in nursing piglets co-infected with PEDV.

  • n=390

Why the study?

Little is known about the molecular epidemiology of porcine deltacoronavirus (PDCoV) in southern China where major swine production occurs.

Population

390 fecal samples from swine of various ages from 15 swine farms with reported diarrhea in southern China

Comparison

PDCoV detection compared to PEDV, TGEV, and Rota C

Design

Observational cross-sectional study using RT-PCR

Authors

SZShao‐Lun ZhaiXinjiang Agricultural UniversityWWWen-Kang WeiGuangdong Academy of Agricultural SciencesXLXiaopeng LiHandan College

Discussion

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Implication

Warrants continued surveillance for PDCoV in swine populations; leaves open its independent contribution to diarrhea beyond PEDV co-infection.

Study Design

Type

Observational (n=390)

Multicenter

Yes

Structured PICO

P
Population
390 fecal samples from swine of various ages across 15 commercial farms with reported diarrhea in southern China.
O
Outcome
Prevalence of PDCoV and other enteric viruses (PEDV, TGEV, Rota C) and phylogenetic analysis of spike (S) and nucleocapsid (N) genes.

PDCoV is present at a low prevalence in southern China and co-infects with PEDV, with circulating strains phylogenetically clustering with other Chinese isolates.

Limitations

  • Limited sample size, particularly for archived samples from 2012 to 2014
  • Limited number of obtained PDCoV sequences for recombination analysis
  • limited samples

Cite This Study

Zhai et al. (2016) conducted an observational in Diarrhea (n=390). Porcine deltacoronavirus (PDCoV) was evaluated on Prevalence of PDCoV. Porcine deltacoronavirus was detected in 1.28% of fecal samples from swine with diarrhea in southern China, exclusively in nursing piglets and always co-infected with porcine epidemic diarrhea virus.

synapsesocial.com/papers/6aad0f1ba03bca6a43e04acehttps://doi.org/10.1186/s12985-016-0591-6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Newly Emerged Porcine Deltacoronavirus Associated With Diarrhoea in Swine in China: Identification, Prevalence and Full-Length Genome Sequence Analysis2015 · 238 citations
  2. 2Complete Genome Sequence of Porcine Deltacoronavirus Isolated in Thailand in 20152016 · 33 citations
  3. 3Autochthonous Melioidosis in Humans, Madagascar, 2012 and 20132014 · 22 citations
  4. 4Discovery of Seven Novel Mammalian and Avian Coronaviruses in the Genus Deltacoronavirus Supports Bat Coronaviruses as the Gene Source of Alphacoronavirus and Betacoronavirus and Avian Coronaviruses as the Gene Source of Gammacoronavirus and Deltacoronavirus2012 · 1,758 citations
  5. 5Complete Genome Sequence of a Recombinant Porcine Epidemic Diarrhea Virus Strain from Eastern China2013 · 22 citations