What question did this study set out to answer?

To measure the plasma 25-hydroxyvitamin D response to localized artificial ultraviolet irradiation over a fixed skin area across different age, sex, and health groups.

March 1, 1980Clinical Science

Assessment of Plasma 25-Hydroxyvitamin D Response to Ultraviolet Irradiation over a Controlled Area in Young and Elderly Subjects

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Authors

MDM. DavieUniversity of Chester DLDavid LawsonBrigham and Women's Hospital

Discussion

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Implication

Experimental study reveals consistent 25-hydroxyvitamin D increases following localized ultraviolet irradiation across age and health groups, indicating rapid yet limited cutaneous synthesis.

Key Points

To measure the plasma 25-hydroxyvitamin D response to localized artificial ultraviolet irradiation over a fixed skin area across different age, sex, and health groups.
Administered artificial ultraviolet irradiation to a controlled area of dorsal skin across N=18 subjects (evaluating young vs. old, male vs. female, and normal vs. osteomalacic subjects).
Delivered irradiation over days 1, 3, 5, 8, 10, 12, 15, and 17 (totaling 15 minutes of exposure) and measured circulating 25-hydroxyvitamin D concentrations normalized to plasma volume.
A total of 15 of 18 subjects showed significant plasma 25-hydroxyvitamin D increases after 15 minutes of exposure, whereas no subjects increased after 2.5 minutes.
The calculated increase was 0.024 nmol of 25-hydroxyvitamin D per square centimeter of irradiated skin, with no statistically significant differences observed between age groups, sexes, or normal versus osteomalacic subjects.
Localized dorsal skin irradiation produced a rapid initial surge and subsequent plateau in 25-hydroxyvitamin D, contrasting with prolonged increases seen with whole-body exposure.

Cite This Study

Davie et al. (1980) studied this question.

synapsesocial.com/papers/6aad101707b74b2d3c24c07c https://doi.org/10.1042/cs0580235

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Implication

Experimental study reveals consistent 25-hydroxyvitamin D increases following localized ultraviolet irradiation across age and health groups, indicating rapid yet limited cutaneous synthesis.

Assessment of Plasma 25-Hydroxyvitamin D Response to Ultraviolet Irradiation over a Controlled Area in Young and Elderly Subjects

Discussion

Member takes

Implication

Key Points

Cite This Study

Assessment of Plasma 25-Hydroxyvitamin D Response to Ultraviolet Irradiation over a Controlled Area in Young and Elderly Subjects

Discussion

Member takes

Implication

Key Points

Cite This Study

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