Key result
AC chemotherapy linked to ~240% higher malondialdehyde and reduced antioxidant status vs healthy controls.
Why the study?
The variation and importance of hematological, enzymatic, and oxidative stress markers in women with breast cancer undergoing chemotherapy were not well characterized.
Does chemotherapy alter oxidative stress, hematological, and biochemical parameters in women with breast cancer?
Case-Control (n=80)
No
Does chemotherapy alter oxidative stress, hematological, and biochemical parameters in women with breast cancer?
Absolute Event Rate: 6.535% vs 1.9225%
p-value: p=<0.001
Chemotherapy in breast cancer patients induces significant systemic oxidative stress and adverse hematological and hepatic effects.
Chemotherapy-linked oxidative stress and hematologic changes in breast cancer merit monitoring; leaves open mitigation strategies for prospective trials.
Objective: This study aimed to to evaluate the variation and importance of certain hematological, enzymatic, and oxidative stress markers in women with breast cancer under chemotherapy treatment. Methods: The study comprised forty histopathologically proven female breast cancer patients at Omega Cancer Hospital in Visakhapatnam. All subjects were divided into four groups: a control group of 40 healthy females of similar age, a group of 40 breast cancer patients (before chemotherapy, during chemotherapy, and after chemotherapy), and all subjects were undergoing treatment with anticancer agents. Results: During chemotherapy, lipid peroxidation and Nitric oxide (NO) levels were significantly increased in AC-treated breast cancer patients than in controls. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) were non-significant increase in treatment group than controls. Whereas biochemical profiles, were decreased in treatment group than controls. In AC-treated breast cancer patients, Hematological profiles were found significantly reduced than in controls. Conclusion: Chemotherapy causes a certain amount of systemic oxidative stress, which persists during subsequent clinical interventions and may influence the patients' clinical outcomes. Chemotherapy produced significant adverse effects such as anaemia, neutropenia, leukopenia, thrombocytopenia, and hepatic dysfunction as a side effect of treatment due to disturbed and lowered levels of haematological parameters.breast cancer
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TejaswiPullakanam et al. (2022) conducted a case-control in Breast cancer (n=80). AC regimen (Adriamycin and cyclophosphamide) vs. Healthy controls was evaluated on Malondialdehyde (MDA) levels after treatment (p=<0.001). Chemotherapy with the AC regimen in breast cancer patients significantly increased oxidative stress markers like malondialdehyde and nitric oxide, while reducing hematological profiles and total antioxidant status compared to healthy controls.
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