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April 21, 2022Open Access

Ageing of long-term allogeneic hematopoietic cells recipients compared to their donors

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Authors

MCMichał Cezary CzarnogórskiJSJustyna SakowskaMMMateusz Maziewski

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Overview

Comparative study reveals accelerated CD8+ lymphocyte telomere shortening in allogeneic transplant recipients compared to donors, indicating proliferative stress drives premature immune senescence.

Key Points

  • To assess whether the adaptive immune system undergoes accelerated biological ageing in long-term allogeneic hematopoietic cell transplant recipients compared to their matched donors.
  • Compared molecular markers of ageing between allogeneic hematopoietic cell transplant recipients and their respective donors.
  • Assessed telomere length, proinflammatory cytokine levels, and immunophenotypic profiles across CD4+, CD8+, CD19+, and CD56+ lymphocyte subpopulations.
  • CD8+ lymphocyte telomere length was significantly shorter in recipients than in donors (mean 1.7 kb vs. 2.1 kb, p = 0.02), with similar non-significant trends observed in CD4+ and CD19+ cells.
  • Recipients with fewer infections had higher levels of TNF-a (p = 0.05) and IL-4 (p = 0.003) along with a higher percentage of natural killer cells (22.3% vs. 9.3%, p = 0.04).

Cite This Study

Czarnogórski et al. (2022) studied this question.

synapsesocial.com/papers/6aad11babdb1c3c786e04e55https://doi.org/10.21203/rs.3.rs-1551685/v1
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