Lower levels of senescence in human lung mesenchymal stromal cells compared with lung fibroblasts: implications for tissue regeneration in COPD

We demonstrate that LMSCs are less sensitive to senescence induction by oxidative stress and replication than LFs, which was accompanied by an increased ability to expand. This makes LMSCs more suitable for cell-based therapies in COPD. As senescence affected growth factors involved in alveolar repair, specifically FGF10 expression in both LMSCs and LFs, we additionally suggest that the development of anti-senescence strategies may promote endogenous tissue repair in COPD.