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One way to eliminate cell-membrane destruction by cellular delivery of nanoparticles is the adoption of a natural pathway by encapsulating inorganic particles into protein spheres to enable potentially harmless cellular uptake by endocytosis. The bio-nanoparticles produced show good catalytic efficiency, supporting the survival of cells under oxidative stress if internalized into cells, and the receptor-mediated delivery offers the possibility of controlling cellular uptake by switching off endocytosis with appropriate inhibitors.
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Zhang et al. (2011) studied this question.
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