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Design and synthesize novel 3-aryl- and 3-aralkyl-1,2,3,4-tetrahydro-4-oxo-6-quinazolinesulfonamides to investigate their chemical properties and pharmacological activity.

September 1, 1970Journal of Medicinal Chemistry

Synthesis and activity of some 3-aryl- and 3-aralkyl-1,2,3,4-tetrahydro-4-oxo-6-quinazolinesulfonamides

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Design and synthesize novel 3-aryl- and 3-aralkyl-1,2,3,4-tetrahydro-4-oxo-6-quinazolinesulfonamides to investigate their chemical properties and pharmacological activity.
Synthesized a series of 3-aryl- and 3-aralkyl-substituted 1,2,3,4-tetrahydro-4-oxo-6-quinazolinesulfonamide chemical analogues.
Assessed structure-activity relationships and biological profiles across the generated heterocyclic compounds.
Established synthetic pathways to successfully generate diverse 3-substituted quinazolinesulfonamide derivatives.
Identified functional chemical modifications that modulate biological activity within the quinazolinesulfonamide scaffold.

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Implication

Preclinical medicinal chemistry study demonstrates the synthesis of novel quinazolinesulfonamide derivatives, highlighting potential candidates for therapeutic development.

Cite This Study

Shetty et al. (1970) studied this question.

synapsesocial.com/papers/6aad13fafd92f81f07d21d05 https://doi.org/10.1021/jm00299a022

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Implication

Preclinical medicinal chemistry study demonstrates the synthesis of novel quinazolinesulfonamide derivatives, highlighting potential candidates for therapeutic development.

Synthesis and activity of some 3-aryl- and 3-aralkyl-1,2,3,4-tetrahydro-4-oxo-6-quinazolinesulfonamides

Key Points

Discussion

Implication

Cite This Study

Synthesis and activity of some 3-aryl- and 3-aralkyl-1,2,3,4-tetrahydro-4-oxo-6-quinazolinesulfonamides

Key Points

Discussion

Implication

Cite This Study