Key result
Fish oil effects on AF remain controversial due to study heterogeneity and individual variability.
Why the study?
The effects of fish oil on atrial fibrillation in primary and secondary prevention and after cardiac surgery remain controversial due to study heterogeneity and individual variability.
Do n-3 polyunsaturated fatty acids prevent atrial fibrillation?
Do n-3 polyunsaturated fatty acids prevent atrial fibrillation?
The efficacy of omega-3 fatty acids for atrial fibrillation prevention remains controversial, highlighting the need for future studies to measure fish oil incorporation into cell membranes.
AF prevention with fish oil should not change practice; leaves open efficacy pending membrane incorporation measurements in trials.
Anti-arrhythmic properties of n-3 polyunsaturated fatty acids, at least in part mediated by anti-oxidant, anti-inflammatory and anti-fibrotic power, have been widely proved. Effect of fish oil on atrial fibrillation, both in primary and in secondary prevention and after cardiac surgery, are controversial, mostly due to lack of homogeneity between studies but also due to individual variability in response to fatty acids administration. Inclusion of measurement of incorporation of fish oil into cell membranes, appears to be essential in future studies, to assess their antiarrhythmic effect.
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Annamaria Martino (2016) conducted a review in Atrial fibrillation. n-3 polyunsaturated fatty acids (fish oil) was evaluated. The effect of fish oil on atrial fibrillation remains controversial due to study heterogeneity and individual variability, necessitating measurement of cell membrane incorporation in future studies.
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