Comparison of the Central Retinal Vessel Diameter Between Glaucomatous and Normal Eye

Q: What are the key findings of this study?

Patients with normal-tension glaucoma and primary open-angle glaucoma had significantly narrower central retinal vessel diameters compared to normal control eyes (p<0.05).

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Glaucoma (Normal-tension and Primary open-angle) (n=80). Intervention: Glaucoma (NTG and POAG) vs. Normal healthy eyes. Primary outcome: Central retinal arteriole equivalent (CRAE) (p=<0.05).

Q: What does this research mean for the field?

Patients with normal-tension glaucoma and primary open-angle glaucoma exhibit significantly narrower central retinal vessel diameters compared to normal control eyes. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Min Wook Chang; Yong Yeon Kim

doi:10.3341/jkos.2009.50.5.738

January 1, 2009Journal of the Korean Ophthalmological SocietyOpen Access

Comparison of the Central Retinal Vessel Diameter Between Glaucomatous and Normal Eye

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Key result

Normal-tension and primary open-angle glaucoma linked to ~8% narrower central retinal vessels versus controls.

P<0.05
n=80

Study Design

Type

Cross-Sectional (n=80)

Blinding

Single-blind

Multicenter

No

PICO

P

Population

80 adults aged 40-70 years with newly diagnosed normal-tension glaucoma, primary open-angle glaucoma, or normal eyes, free of systemic vascular diseases.

E

Exposure / Comparator

Glaucoma (NTG and POAG) vs Normal healthy eyes

O

Primary Outcome

Central retinal arteriole equivalent (CRAE), p=<0.05

Main Result

Absolute Event Rate: 108.5% vs 117.7%

p-value: p=<0.05

Limitations

Retrospective design could not evaluate glaucoma progression.
Lack of data on factors affecting vessel diameter such as smoking, alcohol, blood pressure, and cholesterol.
Minimum measurement unit of 10 μm limited precision.
Small sample size prevented correlation analysis between RNFL thickness and vessel diameter.

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Abstract

고려대학교 의과대학 안과학교실목적: 정상안압녹내장 환자와 원발개방각녹내장 환자 및 정상인을 대상으로

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Cite This Study

Chang et al. (2009) conducted a cross-sectional in Glaucoma (Normal-tension and Primary open-angle) (n=80). Glaucoma (NTG and POAG) vs. Normal healthy eyes was evaluated on Central retinal arteriole equivalent (CRAE) (p=<0.05). Patients with normal-tension glaucoma and primary open-angle glaucoma had significantly narrower central retinal vessel diameters compared to normal control eyes (p<0.05).

synapsesocial.com/papers/6aad16068ce5aa9802a87822 https://doi.org/10.3341/jkos.2009.50.5.738

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Comparison of the Central Retinal Vessel Diameter Between Glaucomatous and Normal Eye

Study Design

PICO

Main Result

Limitations

Ask about this paper

Abstract

Discussion

Cite This Study

Comparison of the Central Retinal Vessel Diameter Between Glaucomatous and Normal Eye

Study Design

PICO

Main Result

Limitations

Ask about this paper

Abstract

Discussion

Cite This Study

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