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February 23, 2018Molecular Therapy — Methods & Clinical DevelopmentOpen Access

A Non-integrating Lentiviral Approach Overcomes Cas9-Induced Immune Rejection to Establish an Immunocompetent Metastatic Renal Cancer Model

Junhui Hu Shiruyeh Schokrpur Maani M. Archang Kip Hermann Allison C. Sharrow Prateek Khanna Jesse Novak Sabina Signoretti Rupal S. Bhatt Beatrice S. Knudsen Hua Xu Lily Wu

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Abstract

) gene knockout RENCA cell line in BALB/c mice, generating an improved model of immunocompetent, metastatic renal cell carcinoma (RCC).

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Hu et al. (2018) studied this question.

synapsesocial.com/papers/6aad1627d314039dc13de8af https://doi.org/10.1016/j.omtm.2018.02.009

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