Key result
Hypertensive disorders of pregnancy linked to ~61% higher CVD risk, rising further with chronic hypertension.
Why the study?
Hypertensive disorders of pregnancy occur in up to 10% of pregnancies and are associated with increased risk of future cardiovascular disease and chronic hypertension, but their impact on CVD risk in middle- and older-aged Japanese women was examined.
Does a history of hypertensive disorders of pregnancy increase the risk of cardiovascular disease in middle- and older-aged Japanese women?
Cross-Sectional (n=26,024)
Does a history of hypertensive disorders of pregnancy increase the risk of cardiovascular disease in middle- and older-aged Japanese women?
Odds Ratio: 1.61 (95% CI 1.03–2.53)
p-value: p=0.0370
A history of hypertensive disorders of pregnancy, especially when combined with chronic hypertension, significantly increases the risk of future cardiovascular disease in middle- and older-aged women.
Supports incorporating pregnancy history into women's CVD risk evaluation; extends evidence to Japanese cohorts but remains hypothesis-generating.
AIM: Hypertensive disorders of pregnancy (HDP) are estimated to occur in up to 10% of all pregnancies and are associated with an increased risk of future cardiovascular disease (CVD) and chronic hypertension (HT). Therefore, we examined the impact of a history of HDP on CVD possibility in middle- and older-aged Japanese women. METHODS: We used the Tohoku Medical Megabank database to obtain the data of 26,024 menopausal women who were aged ≥ 50 years, had children, did not smoke, and did not have chronic kidney disease and to analyze the relationship between HDP history and CVD. RESULTS: was the highest in the HDP＋ HT＋ group compared to the other groups (43.4%, 24.0%, and 45.2%, respectively). Adjusted odds ratio (OR) for the combined six CVD categories was higher for those with a history of HDP alone (OR [95% confidence interval [CI]]: 1.61 [1.03-2.53]). Moreover, the OR was significantly higher for those with combination with HDP history and HT (OR [95% CI]: 4.11 [3.16-5.35]). The prevalence of individual CVD was also the highest in the HT＋ HDP＋ group. CONCLUSION: An HDP history can influence the risk of CVD in Japanese women, indicating the importance of information about pregnancy outcomes in health management.
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Egawa et al. (2023) conducted a cross-sectional in Cardiovascular disease risk (n=26,024). History of hypertensive disorders of pregnancy (HDP) vs. No history of HDP was evaluated on Combined six cardiovascular disease categories (OR 1.61, 95% CI 1.03-2.53, p=0.0370). A history of hypertensive disorders of pregnancy alone was significantly associated with an increased risk of cardiovascular disease (OR 1.61), which further increased when combined with hypertension (OR 4.11).
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