Key result
Altered FTO expression drives obesity susceptibility through effects on adipose tissue development and function.
Why the study?
Emerging evidence implicates adipose tissue development and function in the causal relationship between FTO expression perturbations and obesity, beyond central effects on food intake.
This review highlights the role of FTO in adipose tissue development and function, providing a mechanistic basis for its association with obesity susceptibility.
Hypothesis-generating for FTO modulation in obesity; extends mechanistic understanding but does not support practice change.
In 2007, FTO was identified as the first genome-wide association study (GWAS) gene associated with obesity in humans. Since then, various animal models have served to establish the mechanistic basis behind this association. Many earlier studies focussed on FTO's effects on food intake via central mechanisms. Emerging evidence, however, implicates adipose tissue development and function in the causal relationship between perturbations in FTO expression and obesity. The purpose of this mini review is to shed light on these new studies of FTO function in adipose tissue and present a clearer picture of its impact on obesity susceptibility.
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Merkestein et al. (2015) conducted a review in Obesity. FTO expression perturbations was evaluated on Obesity susceptibility and adipocyte development. Perturbations in FTO expression are causally linked to obesity susceptibility through effects on adipose tissue development and function.
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