Oral pretreatment of rats with chlorinated hydrocarbon insecticides greatly increases their resistance to poisoning by organic phosphate insecticides. Previous work in this laboratory demonstrated that the pretreatment is followed by a rise in the serum aliesterase level. Aldridge has shown that A-aliesterase is capable of hydrolyzing paraoxon (an organic phosphate). It is suggested that an increase in the level of this organophosphate hydrolyzing enzyme plays a part in the protection observed.
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Ball et al. (1954) studied this question.