Key result
MMP-3 and MMP-9 levels predict fatal and nonfatal complications with a ~70% positive prognostic value.
Why the study?
The prognostic value of matrix metalloproteinase-3 and -9, and NT-pro-natriuretic peptide for fatal and nonfatal complications in Q-wave myocardial infarction patients was unclear.
Do matrix metalloproteinase-3, matrix metalloproteinase-9, and NT-pro-natriuretic peptide predict fatal and nonfatal complications in patients with Q-wave myocardial infarction?
Cohort (n=85)
Do matrix metalloproteinase-3, matrix metalloproteinase-9, and NT-pro-natriuretic peptide predict fatal and nonfatal complications in patients with Q-wave myocardial infarction?
Answers are grounded in this paper and cite their sources.
Matrix metalloproteinase-3 and -9 demonstrate strong prognostic value for predicting complications and may help stratify cardiovascular mortality risk in patients with Q-wave myocardial infarction.
OBJECTIVE: The aim of this study was to compare the prognostic value of matrix metalloproteinase-3 and -9, and NT-pro-natriuretic peptide for fatal and nonfatal complications in Q-wave myocardial infarction patients in the acute and postinfarction periods. PATIENTS AND METHODS: 85 men and women with documented Q-wave myocardial infarction were observed for 1 year after hospitalization. Clinical endpoints were identified through the hospital patient-tracking system, with a review of medical records for each recorded endpoint. Left ventricular ejection fraction and wall motion index were calculated. Measurements of matrix metalloproteinases and NT-pro-natriuretic peptide were performed by an enzyme-linked immunosorbent assay. RESULTS: A cutoff value of 9.7 ng·mL(-1) for matrix metalloproteinase-3 showed the best discriminatory power (sensitivity = 77.8%, specificity = 90.8%). The optimal cutoff value of matrix metalloproteinase-9 was 18.1 ng·mL(-1) (sensitivity, 70.5%; specificity, 75%), and the cutoff for NT-pro-natriuretic peptide was 885 pmol·L(-1) (sensitivity, 58%; specificity, 68.6%). Matrix metalloproteinase-3 and -9 were strongly related with a positive prognostic value of 70% (sensitivity and specificity, 84% and 82%, respectively). CONCLUSION: These data may be helpful for further stratification of patients into cardiovascular mortality risk groups.
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Berezin et al. (2013) conducted a cohort in Q-wave myocardial infarction (n=85). Matrix metalloproteinase-3 and -9, and NT-pro-natriuretic peptide was evaluated on Fatal and nonfatal complications. Matrix metalloproteinase-3 and -9 levels were strongly related to fatal and nonfatal complications, with a positive prognostic value of 70% (sensitivity 84%, specificity 82%).
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