Key result
Pleural fluid ADA level yields ~89% sensitivity for diagnosing TB.
Why the study?
A definite diagnosis of tubercular pleural effusion is problematic in many patients despite advances in pulmonary TB diagnosis and treatment, necessitating evaluation of ADA activity in pleural fluid for early diagnosis.
Does pleural fluid ADA level accurately diagnose tubercular pleural effusion in suspected patients?
Observational (n=105)
No
Does pleural fluid ADA level accurately diagnose tubercular pleural effusion in suspected patients?
Effect estimate: Sensitivity 89.47%, Specificity 48.28%
Pleural fluid ADA is a highly sensitive, simple, and cost-efficient biochemical marker for the early diagnosis of tubercular pleural effusion.
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Limited specificity cautions against standalone use; leaves open validation of combined strategies in larger cohorts.
Modi et al. (2018) conducted an observational in Tubercular pleural effusion (n=105). Pleural fluid adenosine deaminase (ADA) level was evaluated on Diagnosis of tuberculosis (Sensitivity 89.47%, Specificity 48.28%). Pleural fluid ADA level demonstrated a sensitivity of 89.47%, specificity of 48.28%, PPV of 81.93%, and NPV of 63.65% for the diagnosis of tuberculosis.
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