The observation of antibodies to the human immunodeficiency virus type 1 (HIV-1) in the urine of HIV-1 positive individuals has been expanded in a US study by examining the immunoglobulin content of urine from 80 HIV-1 seropositive individuals with no clinical or laboratory evidence of renal dysfunction. IgG components were demonstrated electrophoretically in 54 of the urines and all 54 samples displayed immunological reactivity against anti-gamma heavy-chain antiserum. The prognostic significance of an apparently high frequency of light-chain immunoglobulin dimers in the urine of HIV-1 seropositive individuals is unknown. These observations suggest a potential diagnostic screen for detecting antibodies to HIV-1 in urine which may be useful when blood specimens are not available.
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Cao et al. (1988) studied this question.
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