Rapid evolution of decreased host susceptibility drives a stable relationship between ultrasmall parasite TM7x and its bacterial host

This is the authors' abstract. We don't add key points for this paper.

Significance Cultivation-independent sequencing has revealed enormous numbers of bacterial species. Amongst the most enigmatic are members of the Candidate Phyla Radiation, which are estimated to represent over 26% of all bacterial diversity. This group of ultrasmall bacteria are thought to be mostly symbionts; however, understanding these bacteria is hampered by an inability to culture them. Here, we study TM7x, the only strain of the Candidate Phyla Radiation successfully cultured, and demonstrate that it can be virulent and lethal for its bacterial host. The host, however, can rapidly evolve to a state of reduced susceptibility, which results in a long-term parasitic relationship in which both species persist. These findings provide a rare glimpse into the lifestyle and symbiosis of Candidate Phyla Radiation organisms.