Reproducibility of Chronic and Acute Infarct Size Measurement by Delayed Enhancement-Magnetic Resonance Imaging
Key result
Delayed enhancement MRI shows high reproducibility for measuring infarct size with ~0.5% bias.
- Mean bias -0.5 %LV
- n=21
Why the study?
Infarct size reproducibility by delayed enhancement MRI has not been appropriately established for acute and chronic myocardial infarction.
Is delayed enhancement MRI reproducible for measuring acute and chronic infarct size?
Population
21 patients with acute (10) and chronic (11) myocardial infarction
Comparison
Repeated infarct size measurements by delayed enhancement MRI on consecutive days
Design
Observational reproducibility study
Follow-up
Consecutive days
Authors
Discussion
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Implication
Delayed enhancement MRI demonstrates excellent repeatability for measuring infarct size in both acute and chronic myocardial infarction, supporting its use as a surrogate endpoint.
Key Points
- To evaluate the scan-rescan reproducibility as well as interobserver and intraobserver variability of acute and chronic myocardial infarct size measurements using delayed enhancement MRI.
- Assessed infarct size repeatedly on consecutive days using delayed enhancement MRI in N=21 patients (10 acute MI and 11 chronic MI).
- Calculated reproducibility, interobserver variability, and intraobserver variability using the Bland-Altman method.
- Acute and chronic infarct sizes were 17.1 ± 19.6% LV mass (range 5.1% to 69.8%) and 16.9 ± 9.9% LV mass (range 2.0% to 36.0%), respectively.
- The scan-to-scan bias between the first and second imaging sessions was -0.5% LV mass (limits of agreement ±2.4% LV mass), with a bias of -0.7% LV mass (limits ±3.2%) for acute MI and -0.4 ± 1.3% LV mass for chronic MI.
- Intraobserver and interobserver variabilities showed a mean bias of 0.3% LV mass (limits of agreement ±1.7% LV mass) and -0.7% LV mass (limits of agreement ±2.2% LV mass), respectively.
Study Design
Type
Observational (n=21)
Structured PICO
Is delayed enhancement MRI reproducible for measuring acute and chronic infarct size?
P
Population
21 patients with acute (n=10) or chronic (n=11) myocardial infarction undergoing repeated delayed enhancement MRI scans on consecutive days.
E
Exposure
Delayed enhancement (DE) magnetic resonance imaging (MRI) performed repeatedly on consecutive days
O
Outcome
Reproducibility, interobserver, and intraobserver variabilities of infarct size (IS) assessed by Bland-Altman methodsurrogate
Main Result
Mean Difference: -0.5
Delayed enhancement MRI demonstrates excellent repeatability for measuring infarct size in both acute and chronic myocardial infarction, supporting its use as a surrogate endpoint.
Cite This Study
Thiele et al. (2006) conducted an observational in Acute and chronic myocardial infarction (n=21). Delayed enhancement magnetic resonance imaging (DE-MRI) vs. Repeated scans (Scan II) was evaluated on Infarct size difference (bias) between scan I and scan II (Mean bias -0.5 %LV). Delayed enhancement MRI demonstrated high reproducibility for infarct size measurement in acute and chronic MI, with a mean bias between consecutive scans of -0.5 %LV (limits of agreement +/-2.4 %LV).