Key result
Cryosurgical cardiac denervation reduces PGP 9.5 immunoreactive nerve area by ~90% in bovine hearts.
Why the study?
The distribution and origins of peptide containing nerves in the bovine heart before and after functional extrinsic denervation by cryosurgery were not fully characterized.
Does cryosurgical cardiac denervation reduce peptide-containing nerves in the bovine heart?
Does cryosurgical cardiac denervation reduce peptide-containing nerves in the bovine heart?
Cryosurgical denervation significantly reduces extrinsic peptide-containing nerves in the bovine heart, suggesting the calf is an appropriate model for comparative studies of human cardiac innervation.
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Does not inform clinical denervation strategies; leaves open species-specific cardiac innervation patterns for further study.
Gordon et al. (1993) studied this question. Cryosurgical cardiac denervation vs. Intact heart (before cryosurgery) was evaluated on Percentage fluorescent area of protein gene product 9.5 immunoreactive nerves. Cryosurgical cardiac denervation in the bovine heart significantly reduced the percentage fluorescent area of protein gene product 9.5 immunoreactive nerves by greater than 90%.
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