Key result
Left-sided radiotherapy is not linked to higher cardiovascular risk versus right-sided radiotherapy in breast cancer.
Why the study?
Risk factors that interact with radiation exposure to the heart to identify candidates for heart-sparing radiotherapy in left breast cancer patients were unclear.
Does left-sided radiotherapy increase the incidence of cardiovascular disease compared to right-sided radiotherapy in women with breast cancer?
Cohort (n=4,333)
No
Does left-sided radiotherapy increase the incidence of cardiovascular disease compared to right-sided radiotherapy in women with breast cancer?
Hazard Ratio: 1.212 (95% CI 0.753–1.95)
Absolute Event Rate: 2.3% vs 1.9%
p-value: p=0.428
In Korean women with breast cancer, traditional risk factors like hyperlipidemia and smoking do not appear to further increase the risk of radiotherapy-related cardiovascular disease when comparing left-sided to right-sided radiotherapy.
May identify high-risk patients for heart-sparing RT; leaves open prospective validation of interactions.
PURPOSE: This study aimed to identify risk factors that have significant interaction with radiation exposure to the heart, and thus to determine candidates for heart-sparing radiotherapy (RT) among women with left breast cancer. METHODS: or invasive breast cancer from 1996 to 2010. Incidence rates of cardiovascular disease were compared between left-sided and right-sided RT, and stratified by age and risk factors such as body mass index (BMI), smoking, hyperlipidemia, hypertension, diabetes, administration of anthracycline, and trastuzumab. RESULTS: <0.001) were the most powerful risk factors for cardiovascular disease. There was no significant factor that further increased the risk of cardiovascular disease after left breast RT compared to right breast RT. CONCLUSION: Although hyperlipidemia and smoking are risk factors for cardiovascular disease, they have not been proven to increase the risk of RT-related cardiovascular disease in Korean women.
No takes yet. Share an insight, caveat, or question.
Cho et al. (2018) conducted a cohort in Breast cancer (n=4,333). Left-sided radiotherapy vs. Right-sided radiotherapy was evaluated on Incidence of cardiovascular disease (HR 1.212, 95% CI 0.753-1.950, p=0.428). Left-sided radiotherapy did not significantly increase the risk of cardiovascular disease compared to right-sided radiotherapy in women with breast cancer (HR 1.212).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: