Key result
Concurrent hypoparathyroidism is linked to worse physical quality of life and muscle function versus hypothyroidism alone.
Why the study?
The impact of concurrent postsurgical hypoparathyroidism on quality of life, muscle function, and postural stability in patients with hypothyroidism was unclear.
Does concurrent hypoparathyroidism worsen quality of life and muscle function in patients with postsurgical hypothyroidism compared to hypothyroidism alone or healthy controls?
Observational
Does concurrent hypoparathyroidism worsen quality of life and muscle function in patients with postsurgical hypothyroidism compared to hypothyroidism alone or healthy controls?
Concurrent hypoparathyroidism in patients with postsurgical hypothyroidism is associated with more severe impairment of physical quality of life and muscle function than hypothyroidism alone.
May warrant closer monitoring of muscle function; leaves open whether parathyroid hormone replacement improves outcomes.
Total thyroidectomy causes postsurgical hypothyroidism (HypoT). Besides HypoT, as a complication patients may also develop hypoparathyroidism (HypoPT). The aim of this study was to assess quality of life (QoL), muscle function, and postural stability in patients with postsurgical hypothyroidism and hypoparathyroidism (HypoT+PT) as compared to patients with postsurgical HypoT and healthy controls. Age- and gender-matched patients on treatment for HypoT+PT and HypoT were recruited from our outpatient clinic. Matched healthy controls were recruited from the general background population. Compared with controls, HypoT was associated with a significantly lower mental summary score, whereas patients with HypoT+PT had a significantly lower physical summary score (Short Form 36 Health Survey questionnaire version 2). Moreover, the physical component score was significantly lower in patients with HypoT+PT compared with HypoT. WHO-5 well-being index was significantly lower in both groups of patients compared with controls, but did not differ between groups of patients. Compared with controls, muscle strength and maximal force production was significantly reduced in HypoT+PT, but not in HypoT. In HypoT+PT, the time spent on the Timed Up & Go test and the Repeated Chair Stands test were significantly longer than in the HypoT group and the control group. Postsurgical HypoT+PT is associated with a more severe impairment of QoL, in particular regarding physical functioning, than HypoT. HypoT+PT patients are also hampered by impaired muscle function. Studies on how to improve well-being and muscle function in HypoT+PT patients are warranted.
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Sikjær et al. (2016) conducted an observational in Postsurgical hypothyroidism and hypoparathyroidism. Concurrent hypoparathyroidism vs. Hypothyroidism alone and healthy controls was evaluated on Quality of life, muscle function, and postural stability. Concurrent hypoparathyroidism in postsurgical hypothyroidism is associated with significantly worse physical quality of life and impaired muscle function compared to hypothyroidism alone.
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