Key result
Multiscale modeling shows external and cellular respiration response times are similar despite lung-tissue transit delays.
Why the study?
The regulation of respiration during exercise and under abnormal conditions involving O2 transport limitations at different body scales is not fully understood.
A multiscale mathematical model demonstrates tight coupling of O2 transport processes from lungs to muscle during moderate exercise, providing a framework to analyze respiratory regulation in disease states.
A multiscale mathematical model was developed to distinguish responses of external and cellular respiration to exercise of moderate intensity. The simulation shows that the characteristic MRTs of external and cellular respiration are similar even when a transit delay exists between the tissue cells and the lungs. The results of our model show that the O2transport processes from lungs to muscle are tightly coupled to provide sufficient O2for working skeletal muscle during exercise in normal subjects. Under abnormal conditions, the effect of O2transport limitation, occurring at a different scale of the body, on internal and external respiration can be examined. Such results can be used for comparative quantitative analysis of the regulation of respiration in subjects suffering from abnormal function associated with disease states (for example, chronic obstructive pulmonary disease, diabetes, and congenital heart disease).
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Zhou et al. (2009) studied Respiration during exercise. Multiscale mathematical model was evaluated on Mean response times (MRTs) of external and cellular respiration. A multiscale mathematical model simulation showed that the characteristic mean response times of external and cellular respiration are similar even with a transit delay between tissue cells and lungs.
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