A study was made on the sensitivity of a magnetoresistive DNA-chip platform being developed for cystic fibrosis diagnostics. The chip, comprised of an array of 2.5×80μm2 U-shaped spin-valve sensors integrated within current line structures for magnetic label manipulation, enabled the detection at 30Hz of 250nm magnetic nanoparticles from 100pM down to the pM range (or a target DNA concentration of 500pM). It was observed that the sensor response increased linearly with label concentration. Noise spectra obtained for these sensors showed a thermal noise of 10−17V2∕Hz with a 1∕f knee at 50kHz at a 1mA sense current, showing that lower detection limits are possible.
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Ferreira et al. (2006) studied this question.
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